Between 12/1/81 and 7/1/93 705 patients with HIV infection were hospitalized at EMC. Excluding KS and Lym, 18 pts. with neoplastic disorders were identified including testicular (3), brain glioma (3), lung (3), plasmacytoma (3) colon (1), urinary bladder (1), cervix (1), acute myelomonocytic leukemia (1), mesothelioma of pleura (1), malignant nucocele appendix (1). Given the mean age of 37 years, the incidence of glioma and plasmacytoma appears higher than in the general population. Additionally, 3 tumors, a squamous cell of the lung, a transitional cell of the bladder and a mesothelioma were highly aggressive with little response to chemotherapy. All tumors other than cervix (1), colon (1) and lung (1) received combination chemotherapy, but only one remained in complete remission for more than a year. We conclude that plasmacytoma and glioma occur with greater frequency in HIV+ patients. Their course as well as other tumors is short and the response to chemotherapy is poor. Immune modulators may be needed in addition to chemotherapy to maintain remission.

Bacteremia CD4 Lymphocyte Count Human HIV Infections/*COMPLICATIONS Pseudomonas aeruginosa/*ISOLATION & PURIF Pseudomonas Infections/*COMPLICATIONS Retrospective Studies ABSTRACT

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