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The effect of granulocyte-macrophage colony-stimulating factor on myeloid cells and its clinical applications.
Hill AD; Naama HA; Calvano SE; Daly JM; Department of Surgery, New York
March 30, 1996
J Leukoc Biol. 1995 Dec;58(6):634-42. Unique Identifier : AIDSLINE

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a naturally occurring growth factor produced by several cell types in response to a variety of stimuli. GM-CSF has potent stimulatory effects on the growth and maturation of hematopoietic cells and has profound effects on mature circulating effector cells. Clinical applications of GM-CSF include ameliorating chemotherapy-induced neutropenia and enhancing hematopoietic recovery after bone marrow transplantation. This review evaluates the effect of GM-CSF on myeloid cells and its clinical applications.

Acquired Immunodeficiency Syndrome/THERAPY Anemia, Aplastic/THERAPY Bone Marrow Transplantation Granulocyte-Macrophage Colony-Stimulating Factor/ADVERSE EFFECTS/ *PHARMACOLOGY/THERAPEUTIC USE Hematopoiesis/*DRUG EFFECTS Human Monocytes/*DRUG EFFECTS Neutrophils/*DRUG EFFECTS Signal Transduction Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL