DNA and RNA viruses are being developed as vectors for gene therapy. The early application of vectors focused on recombinant retroviruses as vectors primarily in ex vivo applications of gene therapy. Recombinant adenoviruses have been explited for in vivo applications of gene therapy with the initial application being lung-directed gene transfer for the treatment of cystic fibrosis. Adenoassociated virus is the most recently developed viral based system which has the potential of efficiently integrating genes into nondividing cells. In this presentation, I will sumnmarize the strengths and weaknesses of DNA viral bgased vectors for applications of gene therapy.

DNA Viruses/*GENETICS Dependovirus/GENETICS *Gene Therapy *Genetic Vectors Human RNA Viruses/*GENETICS ABSTRACT

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