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Treatment of malnutrition as a complication of HIV infection.
Kotler DP
November 30, 1996
3rd Conf Retro and Opportun Infect. 1996 Jan 28-Feb 1;:170. Unique

Malnutrition is a common and important complication of HIV infection. Few Studies have concentrated upon the role of decreased food intake in its genesis or the therapeutic effect of feeding. The pathogenesis of decreased intake is multifactorial and includes conditions that impair eating as well as secondary anorexia due to malabsorbtion or metabolic alterations associated with systematic illness. Relative effects of decreases intake outweigh metabolic alterations on a quantitative basis, though the metabolic alterations may be decisive. Studies of feeding have included dietary advice, oral supplements, appetite stimulants, and non-volitional enteral and parenteral regimens. Dietary counseling may be effective in some patients, as may nutritional formulae, though the latter may act as substitutes for food. Appetite stimulants lead to increased intake, though effects on body composition show little increase in body cell mass. Gastrostomy feeding may lead to body cell mass repletion in patients with severe intestinal disease, but not in those with systemic infections. Current studies are comparing the effects of different therapies as well as examining possible synergistic effects of combination therapies.

Energy Metabolism HIV Infections/*COMPLICATIONS/METABOLISM Human Nutrition Disorders/COMPLICATIONS/*DRUG THERAPY Parenteral Nutrition, Total ABSTRACT

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