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NLM AIDSLINE
Kaposi's sarcoma-associated herpesvirus(KSHV/HHV8).
Moore PS; Columbia University School of Public Health, NY, NY.
November 30, 1996
3rd Conf Retro and Opportun Infect. 1996 Jan 28-Feb 1;:167. Unique

KSHV is a newly discovered herpes virus present in AIDS-KS lesions. KSHV can be continuously cultured in E lymphocytes derived from AIDS-related body cavity lymphomas. Ongoing mapping and sequence studies demonstrate that this virus is a gamma-2 herpesvirus that possesses metabolic, structural and transforming genes typically found in other gamma-2 herpesviruses. The virus is difficult to culture in vivo but low-titered transmission to other cells has been achieved. Multiple independent studies have found KSHV in nearly all KS tissues examined to date, including AIDS-KS, classical KS, African endemic KS and post-transplant KS lesions. The virus can be detected in peripheral blood mononuclear cells from AIDS patients prior to onset of KS and serologic studies suggest that AIDS-KS patients have high specific immunofluorescence antibody titers against KSHV which are not present among HIV patients without KS. These studies strongly suggest that KSHV/HHV8 is central to the pathogenisis of KS and possibly other AIDS-related lymphoproliferative disorders. Whether or not this herpesvirus, like most human herpesviruses, is ubiquitous among humans remains to be determined.

Acquired Immunodeficiency Syndrome/*COMPLICATIONS Fluorescent Antibody Technique Herpesviridae/*ISOLATION & PURIF/PATHOGENICITY Human Sarcoma, Kaposi's/ETIOLOGY/*VIROLOGY ABSTRACT

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