Annu Conf Australas Soc HIV Med. 1995 Nov 16-19;7:114 (abstract no.
OBJECTIVE: Treatments for HIV with greater efficacy are currently being
sought through clinical trials. If a trial shows one treatment is
effective, those on the other arm will have received suboptimal therapy
for the duration of the trial. The focus of this study was to examine
the dichotomy of roles for the clinician, who is both physician and
investigator. METHOD: General Practitioners and Hospital doctors
participating in a international phase II clinical drug trial were
interviewed and asked to discuss their attitudes and concerns about
clinical drug trials. Their role as investigator versus clinician was
also examined. RESULTS: The interviews were analysed thematically. All
the doctors shared the belief that trials are necessary and important
but that there are conflicts between the needs of the individual and
collecting data which is reliable and can be generalised. Other issues
discussed were the patient's motives for participation and compliance.
The doctors also expressed concerns regarding the selection and
withdrawal of subjects as well as the effects of trials on their
relationship with patients. CONCLUSION: Effective treatments in HIV are
desired by both patient and clinician. The current means of assessing
new therapies can cause dilemmas for the doctors involved.
Attitude of Health Personnel *Clinical Trials Clinical Trials, Phase
II Human HIV Infections/*DRUG THERAPY Medical Staff, Hospital
Patient Compliance Patient Participation *Physician's Role
Physicians, Family ABSTRACT