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Antiretroviral drug resistance: mechanisms, pathogenesis, clinical significance.
Richman DD; San Diego Veterans Affairs Medical Center, La Jolla,
December 30, 1996
Adv Exp Med Biol. 1996;394:383-95. Unique Identifier : AIDSLINE

The contribution of HIV drug resistance to treatment failure, the relationship of drug resistance to pathogenesis and the impact of resistance in the role of the promising new class of protease inhibitors remain areas of active investigation. A more precise understanding of these aspects of antiretroviral drug resistance will permit the more effective use of available drugs and the design of new drugs and drug regimens.

Antiviral Agents/*PHARMACOLOGY/*THERAPEUTIC USE Drug Resistance, Microbial/GENETICS Human HIV Infections/DRUG THERAPY/VIROLOGY HIV Protease Inhibitors/PHARMACOLOGY Retroviridae/*DRUG EFFECTS/GENETICS Retroviridae Infections/*DRUG THERAPY/PATHOLOGY/VIROLOGY Reverse Transcriptase Inhibitors/PHARMACOLOGY Support, U.S. Gov't, Non-P.H.S. Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL