J Med Vet Mycol. 1996 Mar-Apr;34(2):105-10. Unique Identifier : AIDSLINE
The incidence of Penicillium marneffei infection has increased
substantially, especially in persons with HIV infection. Very little is
known about the natural reservoirs or animal hosts of P. marneffei. This
pathogenic fungus was first isolated from a species of bamboo rat
(Rhizomys sinensis) in Vietnam and later from another rodent species, R.
pruinosus. We studied a total of 75 captured bamboo rats; P. marneffei
could be isolated from the internal organs of 13 of 14 (92.8%) of large
bamboo rats, R. sumatrensis, and of 3 of 10 reddish-brown small bay
bamboo rats, Cannomys badius (30%). All 51 greyish-black C. badius were
negative on culture. Among R. sumatrensis, P. marneffei were frequently
recovered from the lungs (85.7%), spleen (50%) and liver (28.6%). Of the
28 soil samples collected from the bamboo rat burrows and the 67 from
the residential areas of patients with P. marneffei infection, P.
marneffei was isolated from one soil sample collected from a burrow of
R. sumatrensis. The mycological characteristics of P. marneffei isolates
from bamboo rats and humans were very similar. Our data indicate that R.
sumatrensis and C. badius may be important animal hosts of P. marneffei
in northern Thailand.
Animal Disease Reservoirs/*VETERINARY Penicillium/CYTOLOGY/*ISOLATION
& PURIF Rats/*MICROBIOLOGY Support, Non-U.S. Gov't Support, U.S.
Gov't, P.H.S. Thailand JOURNAL ARTICLE