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Natural history of HIV infection in infected Haitians with known date of seroconversion.
Deschamps MM; Pape JW; Jhohnson WD Jr; Division International Medicine,
January 30, 1997
Int Conf AIDS. 1996 Jul 7-12;11(2):125 (abstract no. We.C.3395). Unique

Objectives: To determine the Natural History of HIV infection in heterosexual seroconverters with known date of seroconversion in Haiti. Methods: From 1987-1995, 34 individuals heterosexually active, with documented date of seroconversion were prospectively followed for the following endpoints: 1. Development of symptomatic conditions (CDC definition). 2. AIDS. 3. Death. Date of HIV seroconversion is midpoint between last HIV (-) and first HIV (+). They were evaluated clinically every 3 months with CD4 count every 6 months. Results: After a median follow up period of 42 months, 13 of 34 seroconverters (38%) become symptomatic. The median time interval between seroconversion and appearance of first symptom is 38 months. Initial manifestations were: lymphadenopathy in 4, herpes zoster in 1, fever in 2, tuberculosis in 1, weight loss in 2, prurigo in 2, fatigue in 1. Nine (9) individuals developed AIDS 52 months post seroconversion 6-85) with an I.R for AIDS of 8.2 per 100 py. Eight (8) of the seroconverters died; all died of AIDS. The time period from seroconversion to death is 76 months. CD4 cell count provides significant prognostic information as a marker of disease progression only among after 5 years of seroconversion. Conclusion: Even in Haiti where individuals are subject to malnutrition and other infections, the majority 21 (62%) of the individuals remained free of symptoms after five (5) years of infection with HIV. The development of AIDS occurs at 5.9 years of infection with an I.R of 8.2 p 100 py. of observation.

*Acquired Immunodeficiency Syndrome/MORTALITY *HIV Infections/MORTALITY *HIV Seropositivity/MORTALITY