translation agency

The women's interagency study (WIHS)-I. Design, methods, sample.
Barkan S; Melnick S; Stonis L; Preston-Martin S; Weber K; Sacks H; Marx
January 30, 1997
Int Conf AIDS. 1996 Jul 7-12;11(2):100 (abstract no. We.B.3252). Unique

Objective: To investigate in women (WM) the spectrum of AIDS-defining and other HIV-related conditions; predictors of genital infections/cervical disease; immunologic/virologic/clinical correlates of disease progression; substance abuse; sexual behavior; health care utilization; and depression, domestic violence, and quality of life. Methods: The WIHS is a longitudinal study of 2080 HIV(+) and 575 HIV(-) high-risk WM enrolled b/w 10/94 and 11/95 at 6 clinical consortia: Bronx/Manhattan; Brooklyn, NY; Washington, DC; Chicago; San Francisco/Bay Area; Los Angeles/So. CA/Hawaii. Eligibility criteria were: greater than or equal 13 years; able/willing to give informed consent; English or Spanish speaker; willing to be (re)tested for HIV; an ambulatory outpatient at enrollment. Participants received a baseline interview; physical/gyn exam; oral exam; tuberculin/anergy testing; STD screen, Pap smear; colposcopy. Blood urine, cervicovaginal lavage fluids, and lesion swabs were collected. Follow up is at six-monthly intervals. This abstract reflects data from 1693 [1364 HIV(+) and 329 HIV(-)] WM enrolled as of 5/1/95. Results: The HIV(+/-) cohorts were comparable in IDU risk 31%/27%); education (63%/63% completed high school); age (median 36/33 yr.); race/ethnicity (Latina 24%/28.5%; Afr-Am 56%/55%; White 19%/16%;Other 2%/1%). HIV(+) WM reported a higher sexual risk of HIV than HIV(-) WM (44%/27%). HIV(+) WM reported a lower household per capita income than HIV(-) WM (less than $5000/year 51% vs.43%, p=.025). Similar proportions in each cohort were married (22%/25%), living with a partner (14%/15%), and had dependent children (62%/62%). Although 30% of each group ranked their overall health as very good/excellent, HIV(+) WM reported more non-HIV-related chronic conditions (high blood pressure, diabetes, lupus) than HIV(-) WM (25%/18%, p=.01). Conclusions: The WIHS HIV(+/-) WM were comparable overall, except for HIV sexual risk and income. This cohort will provide a wealth of information for studies of disease progression and is a valuable resource for identifying study subjects for intensive substudy research. Research hypotheses, description and methods of standardization of study measures and protocols, and screening and enrollment data for the entire cohort of enrolled women will be presented.

*AIDS-Related Opportunistic Infections/COMPLICATIONS *HIV Infections/COMPLICATIONS *Women's Health