translation agency

Interactions between viral and cellular factors during the early steps of HIV infection.
Trono D; Salk Institute, La Jolla, CA.
July 30, 1997
4th Conf Retro and Opportun Infect. 1997 Jan 22-26;:223 (abstract no.

Specific interactions between viral proteins and intracellular trafficking pathways are keys to HIV replication. The nuclear transport of the uncoated HIV-1 nucleoprotein complex is thus governed by the recognition of matrix (MA), Vpr and integrase IN) by the cell nuclear import machinery. This confers HIV-1 with the ability to infect nondividing cells, a property which can be exploited for the design of retroviral vectors allowing for the in vivo delivery, integration, and sustained long-term expression of transgenes into non mitotic cells such as neurons, myocytes, hepatocytes and pancreatic islet cells. After integration, the virus-induced down-regulation of CD4 and MHC1 is mediated by another type of interaction between HIV-1 and intracellular sorting pathways, this type involving the Nef protein and the endocytic apparatus. Our latest results on these phenomena will be presented.