translation agency

NLM AIDSLINE
Differential requirements for survival and proliferation of CD8 naive or memory T cells [see comments]
Tanchot C; Lemonnier FA; Perarnau B; Freitas AA; Rocha B; INSERM U345,
September 30, 1997
Science. 1997 Jun 27;276(5321):2057-62. Unique Identifier : AIDSLINE

The requisite molecular interactions for CD8 T cell memory were determined by comparison of monoclonal naive and memory CD8(+) T cells bearing the T cell receptor (TCR) for the HY antigen. Naive T cells required only the right major histocompatibility complex (MHC) class I-restricting molecule to survive; to expand, they also needed antigen. In contrast, for survival, memory cells did not require the restricting MHC allele, but needed only a nonspecific class I; for expansion the correct class I, but not antigen, was required. Thus, maintenance of CD8 T cell memory still required TCR-MHC class I interactions, but memory T cells may have a lower functional activation threshold that facilitates secondary responses.

*CD8-Positive T-Lymphocytes/IMMUNOLOGY *Immunologic Memory *T-Lymphocyte Subsets/IMMUNOLOGY

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