translation agency

[Drugs active against retroviruses]
Brun-Vezinet F; Descamps D; Laboratoire de virologie, Hopital
September 30, 1997
Rev Prat. 1997 Mar 15;47(6):631-8. Unique Identifier : AIDSLINE

Major advances in understanding the pathogenesis and treatment of human immunodeficiency virus (HIV) infection have been made recently. The reverse transcriptase and protease enzymes of HIV are currently the targets of antiretroviral therapy. Nucleoside analogues were the first class of antiretroviral drugs which demonstrated antiviral activity in treating patients. More recently protease inhibitors have provided new approaches in the treatment of HIV infection, with encouraging trial results in patients receiving combined therapy. This review presents their mechanisms of activity and patterns of resistance. Apart from these main drug groups many new compounds are under development.