J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Dec 1;16(4):254-65.
Hypogonadism is well documented in HIV-infected men, particularly as
they progress to AIDS and in those with symptoms of wasting.
Testosterone deficiency can be diagnosed with simple laboratory tests,
and various treatment options exist. The benefits of androgen
replacement are well documented from a large body of literature and
experience with hypogonadal men without HIV infection. Hypogonadal men
who are given testosterone replacement have improved sexual thoughts and
functioning, more energy, and improved mood. Generally, quality of life
improves with such therapy. Testosterone replacement tends to maintain
or improve lean body mass. The benefit, dose, and timing of testosterone
replacement treatment for men with HIV infection, however, are less
clear and require further study. Appropriate history and a high degree
of clinical suspicion, coupled with relatively simple laboratory
measurements, can confirm the diagnosis of hypogonadism in men with HIV.
Various options for testosterone replacement, including injections of
testosterone esters and the use of transcutaneous patches, are
discussed, as are the uses of pharmacologic doses of testosterone,
primarily for its potential anabolic effect.
Administration, Cutaneous Administration, Oral Drug Delivery Systems
Human Hypogonadism/DIAGNOSIS/*DRUG THERAPY/ETIOLOGY HIV
Infections/*COMPLICATIONS/DRUG THERAPY Injections, Intramuscular Male
Scrotum Testosterone/ADMINISTRATION & DOSAGE/DEFICIENCY/*THERAPEUTIC
USE JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL