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Interferon therapy for Japanese hemophiliacs with chronic hepatitis C.
Miura T; Meguro T; Takayama S; Yamada K; Department of Pediatrics, Haga
March 30, 1998
Acta Paediatr Jpn. 1997 Oct;39(5):556-8. Unique Identifier : AIDSLINE

Eight Japanese hemophiliacs with chronic hepatitis C (CHC) received interferon (IFN) therapy and four of them (50%) responded completely. Non-responders included 3 double-infected patients: 1 with hepatitis B virus (HBV) and 2 with human immunodeficiency virus-1 (HIV-1). In one of the patients with HIV-1 double infection, the absolute number of CD4+ lymphocytes decreased during IFN therapy. These findings suggest that hemophiliac patients with CHC can respond well to IFN therapy, but in patients who are double-infected with HBV and HIV-1, the indication of IFN therapy should be considered seriously.

*HIV-1 *Hemophilia/COMPLICATIONS *Hepatitis C/THERAPY *Hepatitis, Chronic/THERAPY *Interferon-beta/THERAPEUTIC USE