translation agency

NLM AIDSLINE
Nonsymmetrically substituted cyclic urea HIV protease inhibitors.
Wilkerson WW; Dax S; Cheatham WW; DuPont Merck Pharmaceutical Company,
March 30, 1998
J Med Chem. 1997 Dec 5;40(25):4079-88. Unique Identifier : AIDSLINE

A series of nonsymmetrically substituted cyclic ureacarboxamides was synthesized and evaluated for antiviral activity as a function of the inhibition of HIV-protease. Selected protease inhibitors were also evaluated for oral bioavailability. The synthesis, pharmacology, quantitative structure-activity relationship (QSAR), and pharmacokinetics for the series will be discussed.

*Anti-HIV Agents/CHEMICAL SYNTHESIS *HIV Protease Inhibitors/CHEMICAL SYNTHESIS *Urea/CHEMICAL SYNTHESIS

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