J Am Diet Assoc. 1997 Dec;97(12):1377-81. Unique Identifier : AIDSLINE
OBJECTIVE: To determine whether reduced serum or plasma protein and
micronutrient levels are common in children infected with the human
immunodeficiency virus (HIV) and whether these levels are different in
children with growth retardation compared to those with normal growth.
SUBJECTS: Children were separated into three groups: (a) HIV-infected
with growth retardation (HIV + Gr); (b) HIV-infected with normal growth
(HIV+); (c) HIV-uninfected with normal growth (HIV-). All children were
afebrile and free of acute infection at the time of study. During a
24-hour stay in the Pediatric Clinical Research Unit, blood was drawn
for analysis of total protein, albumin, zinc, selenium, and vitamin A
levels; growth measurements were obtained; and dietary intake was
assessed by 24-hour weighed food intake and 24-hour dietary recall.
STATISTICAL ANALYSIS: Mean differences between groups were assessed by
analysis of variance, and differences in the frequency of nutrient
deficiency were determined by chi 2 analysis. RESULTS: Thirty-eight
children between 2 and 11 years of age were studied: 10 HIV + Gr, 18
HIV+, and 10 HIV-. No statistically significantly differences were noted
in mean levels of albumin, prealbumin, zinc, and selenium. Mean serum
level of vitamin A was significantly higher in the HIV + Gr group than
in the other two groups. There were no significant differences between
groups in the frequency of deficiency for any nutrient studied. Mean
energy and nutrient intake was similar among groups.
APPLICATIONS/CONCLUSIONS: Abnormal serum or plasma protein or
micronutrient levels were uncommon in this cohort of HIV-infected
children, even in children with growth retardation. Routine monitoring
of the level of proteins and micronutrients studied is unnecessary in
the absence of specific clinical indicators of deficiency.
*Child Nutrition/PHYSIOLOGY *HIV Infections/BLOOD
*Micronutrients/METABOLISM *Nutritional Status *Serum