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Prevalence study of HIV antibodies in patients with non-Hodgkin's lymphoma (NHL) in Lagos, Nigeria.
Akinsete I; Akanmu AS; Analo HI; Njoku OS; Okany CC; Army Base Hospital,
December 30, 1998
Int Conf AIDS. 1998;12:1107 (abstract no. 60581). Unique Identifier :

BACKGROUND: The incidence of NHL has been noted to be increasing by 2-3% per year in the last two decades. This has been aetiologically attributed to immunosuppression associated with HIV infection. We tested this association by comparing the seroprevalence of HIV antibodies in Patients with lymphoid malignancies (CLL and NAL) and healthy bolld donors. METHOD: Routine blood donors were recruited over a period of 3 months and patients with lymphoid malignancies were recruited over a period of 15 months. They were screened for HIV antibodies using an E1A technique. Positive specimens were confirmed by Western blot. RESULTS: A total of 406 donors were screened. 20 (4.9%) were positive for HIV-1. A total of 30 patients (20 with NHL and 10 with CLL) were screened.5 (25%) of NHL patients were positive for HIV-1, None of CLL patient was positive. HIV-1 is prevelent in NHL patients than in normal donor population in Lagos. (P less than 0.05, P = 0.0047). CONCLUSION: HIV induced immunosuppression may be the predominant aetiological factor responsible for the increasing incidence of NHL worldwide.

MEETING ABSTRACTS Human HIV Antibodies/BLOOD/*IMMUNOLOGY HIV Infections/BLOOD/COMPLICATIONS/EPIDEMIOLOGY/*IMMUNOLOGY Lymphoma, AIDS-Related/BLOOD/EPIDEMIOLOGY/*IMMUNOLOGY Lymphoma, Non-Hodgkin/BLOOD/COMPLICATIONS/EPIDEMIOLOGY/ *IMMUNOLOGY Nigeria/EPIDEMIOLOGY Prevalence

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