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Profile of HIV patients and compliance to primary prophylaxis therapy to tuberculosis (TB) in an out-patient clinic in Belo Horizonte, Brazil, July 95 June 97.
Tupinambas U; Greco DB; Moll SS; Diniz LM; Xavier LF; Menezes MM; Diniz
December 30, 1998
Int Conf AIDS. 1998;12:293 (abstract no. 22156). Unique Identifier :

OBJECTIVES: To evaluate the characteristics of HIV patients and compliance to prophylaxis for TB (INH). METHODOLOGY: From 87 HIV+ patients who were started on primary TB prophylaxis (July 95 to June 97) in an out-patient clinic the following data was evaluated from 82 of them (five were lost to follow up): gender, age, CD4 level, PPD (5UT), use of antiretrovirals and compliance to TB prophylaxis (Abandon of treatment was considered if patient failed to return for medication after two months). Fifty-four (65.9%) were male and 28 (34.1%) female, with 59.8% of them with ages ranging from 16 to 35 years. HIV risk factors for male: homo-bisexual: 63%; heterosexual 35%; IDU 2%. Risk factors for female: 85.7% acquired HIV through heterosexual contact, 7.1% were IDU; 7.1% through blood transfusion and 3.6% (1 patient) through materno-fetal transmission. From 60 patients with PPD > or = 5 mm, 80% had more than 200 CD4+ cells/mm3. Two were not tested with PPD and 2 had a PPD < 5 mm. From 18 patients anergic to PPD, 55.5% had more than 200 CD4+ cells/mm3 and 8 had a history of recent contact (< 6 months) with a patient with pulmonary TB. Antiretrovirals were being used by 49 individuals (59.8%). Of the 33 (40.2%) who complied with the prophylatic treatment, 18 (54.5%) were also on antiretrovirals. Among the 49 (59.8%) non-compliers, 30 (61.2%) were on antiretroviral therapy. CONCLUSIONS: The rate of non-compliance for TB prophylaxis was very high, especially if we consider that these patients were being followed at a well established specialty clinic, with all drugs (including antiretrovirals) being provided free of charge. It must be noted that the majority of the non-compliers were also in use of antiretrovirals. The reasons for non-compliances is multifactorial and the importance of TB prophylaxis will need to be more emphasized both to the health personnel and to the patients to help change this picture.

MEETING ABSTRACTS Adolescence Adult *Ambulatory Care Facilities Anti-HIV Agents/THERAPEUTIC USE Bisexuality/STATISTICS & NUMER DATA Blood Transfusion/ADVERSE EFFECTS Brazil/EPIDEMIOLOGY Female Heterosexuality/STATISTICS & NUMER DATA Homosexuality, Male/STATISTICS & NUMER DATA Human HIV Seropositivity/*COMPLICATIONS Male *Patient Compliance Risk Factors Substance Abuse, Intravenous/COMPLICATIONS Tuberculosis/*PREVENTION & CONTROL