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Hepatitis C virus (HCV) genotypes and progression of HIV infection in hemophiliacs.
Hatzakis A; Touloumi G; Karafoulidou A; Mandalaki T; Goedert JJ; Athens
December 30, 1998
Int Conf AIDS. 1998;12:147 (abstract no. 13306). Unique Identifier :

BACKGROUND: Hemophilia patients infused with non-heated plasma products were universally infected with HCV. HCV genotype 1 (HCV-1) is associated with poor response to interferon therapy, and it has been suggested that hemophilia patients infected with HCV-1 may experience a more rapid progression of HIV disease. The possible association between HCV-1 and HIV progression was assessed in HCV/HIV coinfected hemophilic subjects followed up within the Multicenter Hemophilia Cohort Study (MHCS). METHODS: Two hundred eighty-one hemophilic subjects with known HIV seroconversion dates were HCV genotyped by RT-PCR and reverse hybridization. Patients from US (n = 152) and Greece (n = 129) were included. AIDS and death risk were estimated by Kaplan-Meier and proportional hazards models, with left truncation for time before the HCV-genotyped sample. RESULTS: The distribution HCV genotypes was 62%, 10%, 11%, 4% and 3% for HCV-1, HCV-2, HCV-3, HCV-4 and mixed types respectively, while in 11% of the samples was not possible to determine the HCV genotype. The distribution was similar in the US and Greek patients. HCV-1 was associated with faster progression to AIDS or death (P = 0.0001 and P = 0.0009, respectively) in both countries. The relative hazard (95% CI, P) (adjusted for age at HIV seroconversion and country) for progressing to AIDS of HCV-1 infected patients vs others was 2.8 (1.5-5.2, P = 0.001). The relative hazard for death was found 2.3 (1.4-3.8, P = 0.001). CONCLUSION: HCV-1 is associated with faster progression to AIDS and death. This finding may have important implications for the treatment of HIV/HCV coinfected patients.

MEETING ABSTRACTS Acquired Immunodeficiency Syndrome/VIROLOGY Cohort Studies Disease Progression Genotype Hemophilia A/*COMPLICATIONS/VIROLOGY Hepatitis C/*COMPLICATIONS Hepatitis C-Like Viruses/*GENETICS Human HIV Infections/*COMPLICATIONS