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NLM AIDSLINE
Correlation of tumor suppressor P53 RNA expression with human immunodeficiency virus disease in rapid and slow progressors.
McLinden RJ; Lewis B; Michael NL; Redfield RR; Birx DL; Kim JH;
July 30, 1999
J Hum Virol. 1997 Nov-Dec;1(1):30-6. Unique Identifier : AIDSLINE

OBJECTIVE: To determine the relation between P53 tumor suppressor RNA expression and human immunodeficiency virus (HIV) disease progression. STUDY DESIGN/METHODS: A quantitative assay of P53 RNA expression was used to analyze a cohort of HIV-negative persons. The assay was then used in longitudinal and cross-sectional studies of HIV slow and rapid progressors. RESULTS: We demonstrate first that P53 expression in peripheral blood mononuclear cells from HIV-1-seronegative persons is minimal. Longitudinal studies in a small cohort of HIV-1-infected slow and rapid progressors reveal that rapid progressors seem to have greater P53 RNA expression over time. This was validated in a cohort of 26 HIV-1-infected persons in whom the expression of P53 RNA was significantly greater in persons with rapid progression of HIV-1 disease. CONCLUSION: These data suggest that P53 RNA expression may play a role in the pathogenesis of HIV-1 disease, though the mechanism of this interaction remains unknown.

JOURNAL ARTICLE Animal Cell Cycle CD4 Lymphocyte Count CHO Cells Disease Progression Gene Expression *Genes, Suppressor, Tumor Hamsters Human HIV Infections/BLOOD/*GENETICS/IMMUNOLOGY/VIROLOGY HIV Seronegativity HIV-1/PHYSIOLOGY Protein p53/ANALYSIS/BLOOD/*GENETICS RNA, Messenger/ANALYSIS Support, U.S. Gov't, P.H.S. Viral Load

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