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Mycobacterium kansasii infection in a Paris suburb: comparison of disease presentation and outcome according to human immunodeficiency virus status. Groupe dEtude Des Mycobacteries de la Seine-Saint-Denis.
Lortholary O; Deniel F; Boudon P; Le Pennec MP; Mathieu M; Soilleux M;
July 30, 1999
Int J Tuberc Lung Dis. 1999 Jan;3(1):68-73. Unique Identifier : AIDSLINE

SETTING: Department of Seine-Saint-Denis, France. OBJECTIVE: To compare the presentation and outcome of Mycobacterium kansasii infections according to human immunodeficiency virus (HIV) status. DESIGN: Retrospective analysis of all the medical charts of adults meeting the diagnostic criteria of the American Thoracic Society for M. kansasii infection between 1991 and 1995. RESULTS: Between 1991 and 1995, 35 cases (23 HIV-[6%] and 12 HIV+ [34%]) were found, giving an annual incidence of 0.5/100000. The following particularities were common to both groups: 1) frequency and prominence of respiratory and general symptoms, 2) rarity of clinically apparent extra-thoracic involvement, 3) bacteriological confirmation mostly obtained with respiratory tract specimens, 4) favourable bacteriological outcome, and 5) low mortality attributable to the mycobacterial infection. The most striking differences concerned chest radiography: HIV- patients had apical cavitated and nodular lesions, while HIV+ patients exhibited a variety of other patterns, including alveolar infiltrates, miliary lesions and/or thoracic lymphadenopathy. CONCLUSION: Apart from pulmonary radiographic differences, presentation and short-term outcome of M. kansasii infections were similar in HIV+ and HIV-patients.

JOURNAL ARTICLE Adult Aged Comparative Study Female France Human HIV Infections/*COMPLICATIONS Lung/RADIOGRAPHY Male Middle Age *Mycobacterium kansasii Mycobacterium Infections, Atypical/*COMPLICATIONS/*DIAGNOSIS/ RADIOGRAPHY Retrospective Studies