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Epidemiology of Streptococcus pneumoniae infections at the Edinburgh City Hospital: 1980-95.
Kalima P; Emmanuel FX; Riordan T; Department of Medical Microbiology,
August 30, 1999
Epidemiol Infect. 1999 Apr;122(2):251-7. Unique Identifier : AIDSLINE

We present data on pneumococcal isolates collected from deep and superficial sites over a 16-year period at the Edinburgh City Hospital. The 10 most frequent serotypes overall were 6, 19, 11, 9, 3, 14, 1, 15 and 18 in children and 19, 23, 6, 6, 9, 11 3, 15, 14, 22 and 4 in adults. Over 88% (2588/2932, 88.3%) of these pneumococci were of serotypes represented in the 23-valent polysaccharide pneumococcal vaccine. Within the 20-45 years age group, 228/434 (52.5%) of specimens were from HIV-infected individuals. The isolations showed a seasonal distribution with peaks in February and troughs in September. The annual numbers of blood culture isolates showed an upward trend. Recurrent isolations were more frequent in HIV-infected individuals (49/132, 37%) than in non-HIV-infected individuals (218/2421, 9.9%) (relative risk = 5.05, 95% confidence interval, 3.46-7.03). The prevalence of resistance to penicillin and erythromycin was lower than that reported in other parts of the UK.

JOURNAL ARTICLE Adolescence Adult Age Distribution Aged Aged, 80 and over Bacteremia/MICROBIOLOGY Child Child, Preschool Erythromycin/PHARMACOLOGY *Hospitals, Urban Human HIV Infections/*COMPLICATIONS Infant Infant, Newborn Microbial Sensitivity Tests Middle Age Penicillins/PHARMACOLOGY Pneumococcal Infections/*EPIDEMIOLOGY/MICROBIOLOGY Scotland/EPIDEMIOLOGY Seasons Serotyping Streptococcus pneumoniae/*CLASSIFICATION/DRUG EFFECTS/*ISOLATION & PURIF