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Transcontinental spread of multidrug-resistant Mycobacterium bovis.
Long R; Nobert E; Chomyc S; van Embden J; McNamee C; Duran RR; Talbot J;
September 30, 1999
Am J Respir Crit Care Med. 1999 Jun;159(6):2014-7. Unique Identifier :

Globally, the proportion of all cases of tuberculosis (TB) caused by drug-resistant strains is increasing. We report the case of a Canadian citizen who acquired a highly drug-resistant strain of Mycobacterium bovis while visiting a relative with AIDS-related tuberculosis in Spain. The origin of the strain was traced using spoligotyping, a polymerase chain reaction (PCR)-based fingerprint technology, and the European DNA database. The level of primary drug resistance-all five first-line drugs and 19 of 21 second-line drugs-in this case was unprecedented in Canada. Isolation of this strain from a Canadian citizen represents the first report of its appearance in this hemisphere. The infection was contained and combined medical-surgical treatment delivered.

JOURNAL ARTICLE Acquired Immunodeficiency Syndrome/COMPLICATIONS/TRANSMISSION Antibiotics/THERAPEUTIC USE Canada Case Report Drug Therapy, Combination Female Human Middle Age Mycobacterium bovis/*PHYSIOLOGY Radiography, Thoracic Support, Non-U.S. Gov't Tomography, X-Ray Computed Tuberculosis Tuberculosis, Multidrug-Resistant/COMPLICATIONS/DRUG THERAPY/ SURGERY/*TRANSMISSION Tuberculosis, Pulmonary/COMPLICATIONS/DRUG THERAPY/SURGERY/ *TRANSMISSION