Clin Exp Immunol. 1999 Sep;117(3):524-8. Unique Identifier : AIDSLINE
Serological rebounds occur frequently in patients with congenital
toxoplasmosis, but remain poorly understood. A link between Th1 and Th2
cytokines and the pathophysiology of infectious diseases has been
reported. Production of interferon-gamma (IFN-gamma) and IL-4 in
supernatants of whole blood after in vitro specific Toxoplasma gondii
stimulation and serum-specific IgE levels were studied in 31
congenitally infected children. IFN-gamma was produced at higher levels
by lymphocytes from children with stable congenital toxoplasmosis (n =
18) than from children showing serological rebound (n = 13) (P < 0.04).
Conversely, supernatants from children with serological rebound showed
higher levels of IL-4 than those from children with stable congenital
toxoplasmosis (P < 0.03). The polarized Th2 response was confirmed by a
greater (IL-4:IFN-gamma) x 100 ratio (P < 0.0001) and production of T.
gondii-specific IgE in six out of 13 children showing serological
rebound. These results suggest a role of Th2 cytokines in
destabilization of congenital toxoplasmosis and perhaps in local
reactivation of the parasite.
JOURNAL ARTICLE Adult Animal Child CD4 Lymphocyte Count Follow-Up
Studies Human IgE/BLOOD/IMMUNOLOGY Immunophenotyping Interferon Type
II/SECRETION Interleukin-4/SECRETION Mice Receptors,
Interleukin-2/BIOSYNTHESIS Th1 Cells/*IMMUNOLOGY Th2 Cells/*IMMUNOLOGY
Toxoplasma/*IMMUNOLOGY Toxoplasmosis, Congenital/*IMMUNOLOGY Tumor