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Hold everything! Holding policies for protecting plasma supplies.
Kaplan EH; Satten GA; Yale School of Management, New Haven, CT
November 30, 1999
Math Biosci. 1999 Sep;160(2):159-73. Unique Identifier : AIDSLINE

In spite of advances in testing technologies for detecting infections such as human immunodeficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C virus (HCV), occasionally blood or plasma is collected that is potentially infectious, but is not detected as such by existing screening tests. We consider the effect of a holding policy for further reducing the number of potentially infectious units that are released for fractionation. The policy dictates a holding period during which all donated units are stored. If a donor tests positive for the infection in question at a subsequent donation, then all of that donor's units currently in storage are discarded. Otherwise, donated units are released at the end of the holding period. In the case of a single disease, we determine optimal holding periods as well as policies that are as effective as the best screening tests currently available.

JOURNAL ARTICLE Blood Banks/*STANDARDS *Blood Donors Blood-Borne Pathogens Cost-Benefit Analysis Human *Models, Biological *Models, Organizational Organization and Administration *Plasma Support, U.S. Gov't, P.H.S.