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Effects of the human immunodeficiency virus (HIV) proteinase inhibitors saquinavir and indinavir on in vitro activities of secreted aspartyl proteinases of Candida albicans isolates from HIV-infected patients.
Korting HC; Schaller M; Eder G; Hamm G; Bohmer U; Hube B; Department of
November 30, 1999
Antimicrob Agents Chemother. 1999 Aug;43(8):2038-42. Unique Identifier :

The effects of therapeutically relevant concentrations of the human immunodeficiency virus (HIV) proteinase inhibitors saquinavir and indinavir on the in vitro proteinase activity of Candida albicans were investigated with isolates from HIV-infected and uninfected patients with oral candidiasis. After exposure to the HIV proteinase inhibitors, proteinase activity was significantly reduced in a dose-dependent manner. These inhibitory effects, which were similar to that of pepstatin A, and the reduced virulence phenotype in experimental candidiasis after application of saquinavir indicate the usefulness of these HIV proteinase inhibitors as potential anticandidal agents.

JOURNAL ARTICLE Anti-HIV Agents/*PHARMACOLOGY Aspartic Proteinases/*ANTAGONISTS & INHIB/ISOLATION & PURIF/ SECRETION AIDS-Related Opportunistic Infections/*MICROBIOLOGY Candida albicans/DRUG EFFECTS/*ENZYMOLOGY/ISOLATION & PURIF Candidiasis, Oral/*MICROBIOLOGY Comparative Study Dose-Response Relationship, Drug Fungal Proteins/ANTAGONISTS & INHIB Human HIV Infections/*MICROBIOLOGY HIV Protease Inhibitors/*PHARMACOLOGY Indinavir/*PHARMACOLOGY Pepstatins/PHARMACOLOGY Saquinavir/*PHARMACOLOGY

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