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Association of plasma levels of human immunodeficiency virus type 1 RNA and oropharyngeal Candida colonization.
Gottfredsson M; Cox GM; Indridason OS; de Almeida GM; Heald AE; Perfect
November 30, 1999
J Infect Dis. 1999 Aug;180(2):534-7. Unique Identifier : AIDSLINE

The pathophysiology of oropharyngeal candidiasis in patients infected with human immunodeficiency virus (HIV) type 1 is poorly understood. Association between oropharyngeal yeast carriage and various clinical factors in HIV-1-infected patients was studied in 83 patients with no clinical evidence of thrush and no recent antifungal use. Of the clinical factors measured, the only correlate of yeast colonization was with plasma HIV-1 RNA levels (P=.001), whereas the correlation with CD4 cell count was poor (P=.36). By multivariable regression modeling, plasma HIV-1 RNA was the only parameter that correlated with the extent of colonization with Candida infection (P=.003). These data indicate that the presence and amount of asymptomatic oropharyngeal yeast carriage in persons with HIV-1 infection is more significantly correlated with plasma HIV-1 RNA levels than with CD4 cell count. Further studies on the effect of HIV-1 on oropharyngeal yeast colonization, infection, and local immunity are warranted.

JOURNAL ARTICLE Adult Aged AIDS-Related Opportunistic Infections/*MICROBIOLOGY/VIROLOGY Candida/*ISOLATION & PURIF Candidiasis, Oral/*MICROBIOLOGY/PHYSIOPATHOLOGY Carrier State/MICROBIOLOGY Colony Count, Microbial Cross-Sectional Studies CD4 Lymphocyte Count Female Human HIV-1/*PHYSIOLOGY Male Middle Age Oropharynx/MICROBIOLOGY RNA, Viral/*BLOOD Support, U.S. Gov't, Non-P.H.S. Viremia/VIROLOGY