J Infect Dis. 1999 Aug;180(2):299-309. Unique Identifier : AIDSLINE
Polymorphic products of genes in the HLA region contributing to
variability in the course of human immunodeficiency virus type 1 (HIV-1)
infection were identified by screening 375 Caucasian seroconverters who
were aggregated from 3 cohorts. AIDS-free time was related to numerous
(15) class I alleles, alone or in conjunction with transporter protein
variants, to homozygosity at the A or B locus, and to alleles of two
class II haplotypes. A prognostic scoring algorithm derived from the 3
cohorts captured multiple HLA contributions to protection or to risk
(relative hazard=0.57-60 per unit increase in score, all P<<.001). The
impact of HLA was strong and appeared independent of the effects of
chemokine receptor/ligand polymorphisms and antiretroviral treatment.
The algorithm also predicted divergent rates of CD4+ cell decline in 2
other groups, totaling 227 seropositive persons (P=.06 - <.001).
Confirmation of these relationships should encourage investigation of
HIV-1 antigen processing and presentation mediated by polymorphisms in
the HLA region.
JOURNAL ARTICLE MULTICENTER STUDY Adult Algorithms Antigen
Presentation Carrier Proteins/*GENETICS/METABOLISM Cohort Studies CD4
Lymphocyte Count Disease Progression Genes, MHC Class I Genes, MHC
Class II Histocompatibility Antigens Class I/*GENETICS/METABOLISM
Histocompatibility Antigens Class II/*GENETICS/METABOLISM
*Homosexuality, Male Homozygote Human HIV
Infections/IMMUNOLOGY/*PHYSIOPATHOLOGY HIV Seropositivity *HIV-1 Male
Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S.