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Consistent associations of HLA class I and II and transporter gene products with progression of human immunodeficiency virus type 1 infection in homosexual men.
Keet IP; Tang J; Klein MR; LeBlanc S; Enger C; Rivers C; Apple RJ; Mann
November 30, 1999
J Infect Dis. 1999 Aug;180(2):299-309. Unique Identifier : AIDSLINE

Polymorphic products of genes in the HLA region contributing to variability in the course of human immunodeficiency virus type 1 (HIV-1) infection were identified by screening 375 Caucasian seroconverters who were aggregated from 3 cohorts. AIDS-free time was related to numerous (15) class I alleles, alone or in conjunction with transporter protein variants, to homozygosity at the A or B locus, and to alleles of two class II haplotypes. A prognostic scoring algorithm derived from the 3 cohorts captured multiple HLA contributions to protection or to risk (relative hazard=0.57-60 per unit increase in score, all P<<.001). The impact of HLA was strong and appeared independent of the effects of chemokine receptor/ligand polymorphisms and antiretroviral treatment. The algorithm also predicted divergent rates of CD4+ cell decline in 2 other groups, totaling 227 seropositive persons (P=.06 - <.001). Confirmation of these relationships should encourage investigation of HIV-1 antigen processing and presentation mediated by polymorphisms in the HLA region.

JOURNAL ARTICLE MULTICENTER STUDY Adult Algorithms Antigen Presentation Carrier Proteins/*GENETICS/METABOLISM Cohort Studies CD4 Lymphocyte Count Disease Progression Genes, MHC Class I Genes, MHC Class II Histocompatibility Antigens Class I/*GENETICS/METABOLISM Histocompatibility Antigens Class II/*GENETICS/METABOLISM *Homosexuality, Male Homozygote Human HIV Infections/IMMUNOLOGY/*PHYSIOPATHOLOGY HIV Seropositivity *HIV-1 Male Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S.