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Interleukin-2 restores natural killer activity inhibited by sera from HIV+ hemophilic patients.
Vulcano M; Galassi N; Felippo M; Vernava D; Olabuenaga S; Division de
December 30, 1999
Medicina (B Aires). 1999;59(2):162-6. Unique Identifier : AIDSLINE

Natural killer (NK) activity is impaired in patients with positive serology for the human immunodeficiency virus (HIV). We previously found an inhibitory effect of sera from hemophilic (He) HIV+ patients on normal NK activity. In the present study, we have further characterized this effect by studying its reversibility, temperature and time incubation dependence. Since interleukin 2 (IL-2) is able to enhance NK levels, we analyzed the capacity of this lymphokine to reverse the effect of He HIV+ sera. We found that when IL-2 activation of NK activity occurred simultaneously or after HIV+ serum-treatment, a significant restoration of NK function was observed. In contrast, preincubation with IL-2 did not affect the inhibitory effect exerted by HIV+ sera.

JOURNAL ARTICLE Acquired Immunodeficiency Syndrome/BLOOD/COMPLICATIONS Cytotoxicity, Immunologic Hemophilia A/*BLOOD/COMPLICATIONS Human HIV Infections/*BLOOD/COMPLICATIONS Interleukin-2/*PHARMACOLOGY Killer Cells, Natural/*DRUG EFFECTS/IMMUNOLOGY Support, Non-U.S. Gov't Time Factors