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GB virus C/hepatitis G virus infection in HIV infected patients with haemophilia despite treatment with virus inactivated clotting factor concentrates.
Woelfle J; Berg T; Bialek R; Keller KM; Effenberger W; Wagner N;
December 30, 1999
Arch Dis Child. 1999 May;80(5):429-32. Unique Identifier : AIDSLINE

AIM: To determine the frequency of GB virus C (GBV-C)/hepatitis G virus (HGV) infection before and after switch to the use of virus inactivated concentrates in haemophiliac patients infected with human immunodeficiency virus (HIV). PATIENTS AND METHODS: Initial and follow up sera from 49 children with haemophilia were analysed for the presence of GBV-C/HGV RNA and antibodies to HGV (anti-HGV). All patients had been infected with HIV while receiving concentrates without virus inactivation before 1984 and were subsequently treated with virus inactivated concentrates. RESULTS: In the first available serum sample (1987 or later), two of 49 patients were GBV-C/HGV RNA positive and two further patients were anti-HGV positive. During follow up (mean, 6 years), 14 patients developed markers of GBV-C/HGV infection. Eleven of these had received no blood products except clotting factor concentrates that had been prepared with virus inactivation. CONCLUSIONS: Despite being treated with virus inactivated clotting factor concentrates, HIV positive patients with haemophilia are at an increased risk of manifesting GBV-C/HGV infection. We hypothesise that GBV-C/HGV is transmitted by these clotting factor concentrates. However, we cannot rule out the emergence of markers of GBV-C/HGV infection as a result of the progression of immune impairment in the course of HIV infection.

JOURNAL ARTICLE Adolescence Child Child, Preschool CD4 Lymphocyte Count Drug Contamination Factor VIII/*THERAPEUTIC USE Follow-Up Studies Hemophilia A/COMPLICATIONS/*THERAPY Hepatitis Agents, GB/*ISOLATION & PURIF Hepatitis, Viral, Human/COMPLICATIONS/IMMUNOLOGY/*TRANSMISSION Human HIV Infections/*COMPLICATIONS/IMMUNOLOGY Immunocompromised Host Male Retrospective Studies