NLM AIDSLINE Human T-cell lymphotrophic virus type-I tax gene induces secretion of
human macrophage inflammatory protein-1alpha.
Sharma V; May CC; Department of Biology, University of West Florida,
December 30, 1999
Unique Identifier : AIDSLINE MED/99393322
Human T-cell lymphotropic virus I (HTLV-I) encodes for a 40-kDa protein,
Tax, which is important for the immortalization of T cells. Tax has been
shown to transactivate several cellular genes. In this study, we show
that MIP-1alpha is selectively expressed and secreted in the tax
transfected Jurkat cell line upon mitogen stimulation. Expression of
MIP-1alpha-R mRNA in these cells suggests an autocrine role for this
chemokine in HTLV-I infected T-cells. Induced MIP-1alpha expression and
secretion in PMA/PHA stimulated tax transfected cells correlate with the
noninduction of MNP-1 transcription factor, which is intimately involved
in downmodulating the MIP-1alpha gene. Copyright 1999 Academic Press.