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Transmission of an azole-resistant isogenic strain of Candida albicans among human immunodeficiency virus-infected family members with oropharyngeal candidiasis.
Muller FM; Kasai M; Francesconi A; Brillante B; Roden M; Peter J;
December 30, 1999
J Clin Microbiol. 1999 Oct;37(10):3405-8. Unique Identifier : AIDSLINE

We report transmission of an azole-resistant, isogenic strain of Candida albicans in a human immunodeficiency virus (HIV)-infected family of two children with symptomatic oropharyngeal candidiasis and a mother with asymptomatic colonization over a 5-year period. These findings were confirmed by three different molecular epidemiology methods: interrepeat PCR, Southern hybridization with a C. albicans repetitive element 2 probe, and electrophoretic karyotyping. This study contributes to an evolving understanding of the mode of transmission of C. albicans, particularly in children, and underscores the importance of monitoring specimens from family members of HIV-infected patients.

JOURNAL ARTICLE Antifungal Agents/*PHARMACOLOGY Candida albicans/*DRUG EFFECTS Candidiasis/MICROBIOLOGY/*TRANSMISSION Candidiasis, Oral/MICROBIOLOGY/*TRANSMISSION Child *Disease Transmission, Vertical Drug Resistance, Microbial Female Human HIV Infections/MICROBIOLOGY/*TRANSMISSION Male Pharyngeal Diseases/*ETIOLOGY/MICROBIOLOGY Support, Non-U.S. Gov't

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