Acta Neurol Scand. 1999 Aug;100(2):102-5. Unique Identifier : AIDSLINE
OBJECTIVE: To evaluate the presence of thallium-201 brain uptake
determined by thallium-201 brain SPECT (Tl-201 SPECT) in patients with
progressive multifocal leukoencephalopathy (PML) and AIDS. MATERIAL AND
METHODS: Six AIDS patients with stereotactic biopsy diagnosis of PML
were prospectively evaluated with Tl-201 SPECT, Magnetic Resonance
Imaging (MRI), and proton magnetic resonance spectroscopy (1H-MRS).
Tl-201 SPECT results were compared with 2 patients with AIDS and biopsy
proven primary CNS lymphoma. RESULTS: In all patients with PML, Tl-201
SPECT studies showed lack of uptake while MRI demonstrated subcortical
white matter focal brain lesions and 1H-MRS disclosed metabolic
abnormalities. Intense thallium uptake (uptake ratios of 3.2 and 5.6)
was demonstrated in the 2 patients with primary CNS lymphoma.
CONCLUSIONS: The present study shows that PML lesions are not detectable
on Tl-201 SPECT while MRI and 1H-MRS demonstrate abnormalities, and
intense thallium-201 uptake may be detected in primary CNS lymphoma.
These results suggest that Tl-201 SPECT is a method which, combined with
other non-invasive techniques such as MRI and 1H-MRS, may help in the
diagnostic approach of PML and to differentiate PML from other high
proliferative brain lesions characterized by positive thallium uptake.
JOURNAL ARTICLE Adult AIDS Dementia Complex/*RADIONUCLIDE IMAGING
AIDS-Related Opportunistic Infections/*RADIONUCLIDE IMAGING
Brain/RADIONUCLIDE IMAGING Brain Neoplasms/RADIONUCLIDE IMAGING
Diagnosis, Differential Energy Metabolism/PHYSIOLOGY Female Human
Leukoencephalopathy, Progressive Multifocal/*RADIONUCLIDE IMAGING
Lymphoma, AIDS-Related/RADIONUCLIDE IMAGING Magnetic Resonance Imaging
Male Middle Age Neurologic Examination Nuclear Magnetic Resonance
Support, Non-U.S. Gov't Thallium Radioisotopes/DIAGNOSTIC USE
*Tomography, Emission-Computed, Single-Photon