translation agency

Synthesis of oligonucleotide-intercalator conjugates capable to inhibit HIV-1 DNA integration.
Gottikh MB; Volkov EM; Romanova EA; Oretskaya TS; Shabarova ZA; A.N.
December 30, 1999
Nucleosides Nucleotides. 1999 Jun-Jul;18(6-7):1645-6. Unique Identifier

This investigation is devoted to design of short "switch" oligonucleotides mono- or bi-functionnalized with intercalating agents capable to form a stable triplex with HIV integrase-cognate sequences and inhibit selectively HIV integration. Methods of intercalator incorporation at 5'- and/or 3'-terminal positions or one of the pyrimidine heterocyclic bases are developed.

JOURNAL ARTICLE Base Sequence HIV Integrase Inhibitors/CHEMISTRY/*PHARMACOLOGY HIV Long Terminal Repeat HIV-1/*GENETICS Intercalating Agents/*CHEMISTRY Oligonucleotides/*CHEMISTRY Support, Non-U.S. Gov't Virus Integration/*DRUG EFFECTS