Nucleosides Nucleotides. 1999 Jun-Jul;18(6-7):1645-6. Unique Identifier
This investigation is devoted to design of short "switch"
oligonucleotides mono- or bi-functionnalized with intercalating agents
capable to form a stable triplex with HIV integrase-cognate sequences
and inhibit selectively HIV integration. Methods of intercalator
incorporation at 5'- and/or 3'-terminal positions or one of the
pyrimidine heterocyclic bases are developed.
JOURNAL ARTICLE Base Sequence HIV Integrase
Inhibitors/CHEMISTRY/*PHARMACOLOGY HIV Long Terminal Repeat
HIV-1/*GENETICS Intercalating Agents/*CHEMISTRY
Oligonucleotides/*CHEMISTRY Support, Non-U.S. Gov't Virus