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Allo-immunization elicits CD8+ T cell-derived chemokines, HIV suppressor factors and resistance to HIV infection in women.
Wang Y; Tao L; Mitchell E; Bravery C; Berlingieri P; Armstrong P;
December 30, 1999
Nat Med. 1999 Sep;5(9):1004-9. Unique Identifier : AIDSLINE MED/99401079

We assessed the potential for an allogeneic-based vaccine against HIV infection in women who were allo-immunized with their partners' mononuclear leucocytes to prevent spontaneous recurrent abortion. Within 1 month of allo-immunization, there was significant upregulation in the concentrations of CD8 cell-derived suppressor factor activity, RANTES, and macrophage inflammatory proteins 1alpha and 1beta. Allo-immunization also downregulated the proportion of cells with CCR5 and CXCR4 receptors. We also found a dose-dependent decrease in HIV infectivity of CD4+ cells in vitro after allo-immunization with both primary and T-cell line adapted HIV-1. This study provides a rational basis for an alternative or complementary strategy of allo-immunization against HIV infection.

JOURNAL ARTICLE Abortion, Habitual/IMMUNOLOGY/THERAPY Antigens, CD4/IMMUNOLOGY/METABOLISM Cells, Cultured Chemokines, CC/IMMUNOLOGY/*METABOLISM CD4-Positive T-Lymphocytes/IMMUNOLOGY/VIROLOGY CD8-Positive T-Lymphocytes/*IMMUNOLOGY Female Gene Expression Regulation Human HIV Infections/IMMUNOLOGY HIV-1/IMMUNOLOGY/*PHYSIOLOGY *Immunization Isoantibodies/*IMMUNOLOGY Leukocytes, Mononuclear/IMMUNOLOGY/TRANSPLANTATION Macrophage Inflammatory Protein-1/METABOLISM Male Pregnancy Receptors, CCR5/METABOLISM Receptors, CXCR4/METABOLISM RANTES/METABOLISM Support, Non-U.S. Gov't Suppressor Factors, Immunologic/IMMUNOLOGY/*METABOLISM Virus Replication