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T-cell subsets in schizophrenia: a comparison between drug-naive first episode patients and chronic schizophrenic patients.
Sperner-Unterweger B; Whitworth A; Kemmler G; Hilbe W; Thaler J; Weiss
December 30, 1999
Schizophr Res. 1999 Jul 27;38(1):61-70. Unique Identifier : AIDSLINE

T-cell subsets (CD3+, CD4+, CD8+, NK-cells) and the CD4+/CD8+ ratio were measured in 56 schizophrenic patients admitted to hospital with an acute psychosis. Thirty-five patients with chronic schizophrenia and 21 drug-naive first episode schizophrenic patients were compared with 16 healthy controls. T-cell subsets were quantified in the acute state of the illness (day 0), after 7 days of treatment and at the time of discharge. In the acute state, schizophrenic patients showed higher CD3+ and CD4+ cells (p = 0.05) and a higher CD4/CD8 ratio (p = 0.02) than healthy controls, while NK-cells were lower (p = 0.05). In first episode patients, all T-cell alterations normalized during treatment. In the chronic group the ratio remained high, whereas the initially low number of NK-cells normalized over time. These findings, supporting immune system dysregulation in schizophrenia, are discussed in relation to psychopathology, the stage of illness and effects of medication.

JOURNAL ARTICLE Acute Disease Adult Antipsychotic Agents/ADVERSE EFFECTS/THERAPEUTIC USE Chronic Disease Cytokines/BLOOD CD4-CD8 Ratio/DRUG EFFECTS Female Human Killer Cells, Natural/DRUG EFFECTS/IMMUNOLOGY Male Middle Age Schizophrenia/DRUG THERAPY/*IMMUNOLOGY Support, Non-U.S. Gov't T-Lymphocyte Subsets/DRUG EFFECTS/*IMMUNOLOGY