AIDS Research and TherapyT cell Activation does not drive CD4 decline in longitudinally followed HIV-infected Elite Controllers
<p class="authors">Philomena Kamya<sup>1,2</sup>, Christos M Tsoukas3<sup>,1,2</sup>, Salix Boulet<sup>1,2</sup>, Jean-Pierre Routy<sup>4,1,2</sup>, Réjean Thomas<sup>5</sup>, Pierre Côté<sup>6</sup>, Mohamed-Rachid Boulassel<sup>4</sup>, Bernard Lessard<sup>6</sup>, Rupert Kaul<sup>7</sup>, Mario Ostrowski<sup>7</sup>, Colin Kovacs<sup>8</sup>, Cecile L Tremblay<sup>9</sup> and Nicole F Bernard<sup>3,1,2*</sup><strong> <br /></strong></p>
June 16, 2011
Elite controllers (EC) are a rare subset of HIV infected individuals who control viral load below 50 copies/ml of plasma without treatment.
Thirty four EC were studied. The slope of CD4 count change was available for 25 of these subjects. We assessed immune activation by measuring the percent of CD38+HLA-DR+CD8+ T cells in the EC group and comparing it with that in 24 treatment-naïve HIV disease progressors and 13 HIV uninfected healthy controls.
Compared to HIV uninfected subjects, EC had higher percentages of CD38+HLA-DR+CD8+ T cells (p < 0.001) that was lower than that observed in progressors (p < 0.01). Fifteen of 25 EC had a slope of CD4 count change that was not significantly different from 0 while 3 had a positive and 7 a negative CD4 count slope. Immune activation did not distinguish EC subsets with stable/increasing versus declining CD4 counts.
Elevated immune activation in ECs is not associated with a faster rate of CD4 decline
HIV infection; Elite controllers; activation markers; CD4 count change
*Corresponding author: Nicole F Bernard firstname.lastname@example.org
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