British Journal of Cancer doi:10.1038/bjc.2011.558 (01.12.12)
"Immunodeficiency and AIDS-related pulmonary infections have
been suggested as independent causes of lung cancer among HIV-
infected persons, in addition to smoking," the authors wrote.
The researchers identified 68 lung cancer cases in the Swiss
HIV Cohort Study (SHCS) or through linkage with the Swiss
Cancer Registries (1985-2010); these then were individually
matched to 337 controls by center, gender, HIV transmission
category, age, and calendar period. Conditional logistic
regression was used to estimate odds ratios (OR).
The results showed that 96.2 percent of lung cancer patients
and 72.9 percent of controls were ever smokers, "confirming
the high prevalence of smoking and its strong association with
lung cancer" (OR for current vs. never=14.4, 95 percent
confidence interval: 3.36-62.1).
The researchers found no significant associations between CD4+
cell count and lung cancer, "neither when measured within 1
year (OR for <200 vs. =500=1.21, 95 percent CI: 0.49-2.96) nor
further back in time, before lung cancer diagnosis."
"Combined antiretroviral therapy was not significantly
associated with lung cancer (OR for ever vs. never=0.67, 95
percent CI: 0.29-1.52), nor was a history of AIDS with
(OR=0.49, 95 percent CI: 0.19-1.28) or without (OR=0.53, 95
percent CI: 0.24-1.18) pulmonary involvement," the authors
"Lung cancer in the SHCS does not seem to be clearly
associated with immunodeficiency or AIDS-related pulmonary
disease, but seems to be attributable to heavy smoking," the