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AIDS Treatment Data Network
(ATDN) New information on fungal treatments

November 1, 1994
Treatment Review No. 14; November 1994

New reports have shown that candida infections can become resistant to fluconazole. Resistance means an infection no longer responds to treatment. Fluconazole is used for treatment and prevention of thrush, vaginal candidiasis and other infections caused by C. albicans.

Resistance to other azole drugs used for treatment have also been shown. The drugs are ketoconazole, clotrimazole, and itraconazole.

Although these findings require further study, they suggest that chronic fluconazole therapy in HIV+ patients may be limited by the development of resistance to the drugs. Chronic use of a drug means it is used for a long time to suppress and prevent the disease. People who have become resistant to fluconazole may have to be treated with amphotericin B.

For a Simple Facts Sheet on fungal infections and treatments, call The Network and we will send you one right away.