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AIDS Treatment Data Network
(ATDN) Vitamin A type drug for Kaposi's sarcoma (KS)

November 1, 1995
Treatment Review No. 20; November 1995

Kaposi's sarcoma is a kind of cancer that can cause lesions or marks on the skin. It can sometimes also spread inside the body. Although no treatment is 100% effective at controlling this cancer, some treatments produce benefits. NYU Medical Center is studying a drug which is derived from vitamin A . The drug, 9-cis-retinoic acid, is similar to Retin-A, the drug commonly used for acne (pimples). 9-cis-retinoic acid is a topical cream that is applied directly to KS lesions. It will be given to all participants enrolled in the study. Participants will apply the cream to their lesions twice a day for the first two weeks and then four times a day for the next two weeks. If the cream is effective, participants may be permitted to remain on the study drug. To be eligible for this trial, you cannot have systemic (inside your body) KS or be taking any other treatments for KS.