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CDC HIV/AIDS/Viral Hepatitis/STD/TB Prevention News Update
UNITED STATES: Home Field Advantage: Intravaginal Immunization May Help Protect Against Infection
Staff Writer
November 14, 2012
Medical Xpress (11.12.12) Aids Weekly Plus

Researchers led by John Schiller at the National Cancer Institute have published a study exploring the immune response to intravaginal immunization in mice infected with a strain of the HPV virus carrying a certain antigen. The researchers found that intravaginal immunization significantly increased the number of immune cells present in the vaginal mucosa as compared to a general immune system booster. The results show that area-specific vaccination enhances the local immune system response and may be helpful in developing STD vaccines. The study titled,"Intravaginal Immunization with HPV Vectors Induces Tissue-Resident CD8+ T cell Responses" is published online in the Journal of Clinical Investigation (2012; doi:10.1172/JCI63287).