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AIDS Weekly Plus
Reports Outline Epidemiology Research from Johns Hopkins University Bloomberg School of Public Health

Staff Writer


March 11, 2013



2013 MAR 11 (NewsRx) -- By a News Reporter-Staff News Editor at AIDS Weekly -- Research findings on Epidemiology are discussed in a new report. According to news reporting from Baltimore, Maryland, by NewsRx journalists, research stated, "Parametric and semiparametric competing risks methods were used to estimate proportions, timing, and predictors of acquired immune deficiency syndrome (AIDS)-related and non-AIDS-related mortality among individuals both positive and negative for the human immunodeficiency syndrome (HIV) in the Multicenter AIDS Cohort Study (MACS) and Women's Interagency HIV Study (WIHS) from 1984 to 2008 and 1996 to 2008, respectively. Among HIV-positive MACS participants, the proportion of deaths unrelated to AIDS increased from 6% before the introduction of highly active antiretroviral therapy (HAART) (before 1996) to 53% in the HAART era (p <0.01); the median age of persons who died from non-AIDS-related causes after age 35 years increased from 49.0 to 66.0 years (p <0.01)."

The news correspondents obtained a quote from the research from the Johns Hopkins University Bloomberg School of Public Health, "In both cohorts during the HAART era, median ages at time of non-AIDS-related death were younger for HIV-positive individuals than for comparable HIV-negative individuals (8.7 years younger in MACS (p <0.01) and 7.6 years younger in WIHS (p <0.01)). In a multivariate proportional cause-specific hazards model, unemployment (for non-AIDS death, hazard ratio (HR)=1.8; for AIDS death, HR=2.3), depression (for non-AIDS death, HR=1.4; for AIDS death, HR=1.4), and hepatitis B or C infection (for non-AIDS death, HR=1.8, for AIDS death; HR=1.4) were significantly (p <0.05) associated with higher hazards of both non-AIDS and AIDS mortality among HIV-positive individuals in the HAART era, independent of study cohort."

According to the news reporters, the research concluded: "The results illuminate the changing face of mortality among the growing population infected with HIV."

For more information on this research see: Cause-specific life expectancies after 35 years of age for human immunodeficiency syndrome-infected and human immunodeficiency syndrome-negative individuals followed simultaneously in long-term cohort studies, 1984-2008. American Journal of Epidemiology, 2013;177(2):116-25. (Oxford University Press - www.oup.com/; American Journal of Epidemiology - aje.oxfordjournals.org)

Our news journalists report that additional information may be obtained by contacting N. Wada, Dept. of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Room E7648, Baltimore, MD 21205, United States (see also Epidemiology).

Keywords for this news article include: Maryland, HIV/AIDS, Baltimore, RNA Viruses, Epidemiology, Retroviridae, United States, HIV Infections, Vertebrate Viruses, Primate Lentiviruses, North and Central America, Viral Sexually Transmitted Diseases.

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