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AIDS Weekly Plus
Researchers from Albert Einstein College of Medicine Detail New Studies and Findings in the Area of AIDS/HIV Research
Staff Writer
March 25, 2013


2013 MAR 25 (NewsRx) -- By a News Reporter-Staff News Editor at AIDS Weekly -- New research on AIDS/HIV Research is the subject of a report. According to news reporting out of Bronx, New York, by NewsRx editors, research stated, "Coinfection with HIV and hepatitis C virus (HCV) is common. HIV infection and treatment are associated with hypercoagulability; thrombosis in HCV is underinvestigated."

Our news journalists obtained a quote from the research from the Albert Einstein College of Medicine, "Proposed markers of hemostasis in HIV include higher D-dimer, Factor VIII%, and plasminogen activator inhibitor-1 (PAI-1) antigen and lower total Protein S% (TPS) but have not been examined in HCV. We assessed the independent association of HCV with these 4 measures of hemostasis in a multicenter, prospective study of HIV: the Women's Interagency HIV Study. We randomly selected 450 HCV-infected (anti-HCV+ with detectable plasma HCV RNA) and 450 HCV-uninfected (anti-HCV-) women. HCV was the main exposure of interest in regression models. Four hundred forty-three HCV+ and 425 HCV- women were included. HCV+ women had higher Factor VIII% (124.4% +/- 3.9% vs. 101.8% +/- 3.7%, P< 0.001) and lower TPS (75.7% +/- 1.1% vs. 84.3% +/- 1.1%, < 0.001) than HCV- women, independent of HIV infection and viral load; there was little difference in PAI-1 or log(10) D-dimer. After adjustment for confounders, these inferences remained. HIV infection was independently associated with higher Factor VIII% and log10 D-dimer and lower TPS. HCV was independently associated with higher Factor VIII% and lower TPS consistent with hypercoagulability. Higher Factor VIII% and D-dimer and lower TPS were also strongly associated with HIV infection and levels of HIV viremia, independent of HCV infection. Further investigation is needed to determine if there is increased thrombotic risk from HCV."

According to the news editors, the research concluded: "Studies examining hemostasis markers in HIV infection must also assess the contribution of HCV infection."

For more information on this research see: Association of Hepatitis C With Markers of Hemostasis In HIV-Infected and Uninfected Women in the Women's Interagency HIV Study (WIHS). Jaids-Journal of Acquired Immune Deficiency Syndromes, 2013;62(3):301-310. Jaids-Journal of Acquired Immune Deficiency Syndromes can be contacted at: Lippincott Williams & Wilkins, 530 Walnut St, Philadelphia, PA 19106-3621, USA (see also AIDS/HIV Research).

Our news journalists report that additional information may be obtained by contacting E.M. Kiefer, Albert Einstein College of Medicine, Bronx, NY 10467, United States.

Keywords for this news article include: HCV, Bronx, New York, HIV/AIDS, Virology, Hepatology, RNA Viruses, Retroviridae, United States, HIV Infections, Liver Diseases, Gastroenterology, AIDS/HIV Research, Hepatitis C Virus, Infectious Disease, Vertebrate Viruses, Primate Lentiviruses, Flaviviridae Infections, North and Central America, Digestive System Diseases

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