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AIDS Weekly Plus
Studies from Center for Disease Control and Prevention in the Area of AIDS/HIV Research Described

Staff Writer

April 1, 2013

2013 APR 1 (NewsRx) -- By a News Reporter-Staff News Editor at AIDS Weekly -- Investigators discuss new findings in AIDS/HIV Research. According to news originating from Atlanta, Georgia, by NewsRx correspondents, research stated, "To systematically review epidemiologic evidence assessing whether hormonal contraception alters the risk of HIV transmission from an HIV-positive woman to an HIV-negative male partner. Systematic review. We included articles published or in press through December 15, 2011."

Our news journalists obtained a quote from the research from Center for Disease Control and Prevention, "We assessed studies with direct evidence on hormonal contraception use and HIV transmission, and summarized studies with indirect evidence related to genital or plasma viral load. One study provided direct evidence on oral contraceptive pills (OCPs) or injectable contraception and female-to-male HIV transmission; both injectables [Cox-adjusted hazard ratio (adjHR) 1.95, 95% confidence interval (CI) 1.06-3.58; marginal structural model (MSM) adjusted odds ratio (adjOR) 3.01, 95% CI 1.47-6.16] and OCPs (Cox adjHR 2.09, 95% CI 0.75-5.84; MSM adjOR 2.35, 95% CI 0.79-6.95) generated elevated point estimates, but only estimates for injectables were significant. Findings from 11 indirect studies assessing various hormonal contraception methods and viral genital shedding or setpoint were mixed, and seven of eight studies indicated no adverse effect of various hormonal contraception methods on plasma viral load. The only direct study on OCPs or injectable contraception and female-to-male HIV transmission suggests increased risk with the use of injectables."

According to the news editors, the research concluded: "Given the potential for confounding in observational data, the paucity of direct evidence on this subject, and mixed indirect evidence, additional evidence is needed."

For more information on this research see: Hormonal contraceptive use and female-to-male HIV transmission: a systematic review of the epidemiologic evidence. Aids, 2013;27(4):493-505. Aids can be contacted at: Lippincott Williams & Wilkins, 530 Walnut St, Philadelphia, PA 19106-3621, USA. (Lippincott Williams and Wilkins -; Aids -

The news correspondents report that additional information may be obtained from C.B. Polis, Center Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA, United States (see also AIDS/HIV Research).

Keywords for this news article include: Atlanta, Georgia, HIV/AIDS, RNA Viruses, Retroviridae, United States, HIV Infections, AIDS/HIV Research, Vertebrate Viruses, Primate Lentiviruses, North and Central America, Viral Sexually Transmitted Diseases

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