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AIDS Weekly Plus
Findings from London School of Hygiene and Tropical Medicine Reveals New Findings on AIDS/HIV Research
Staff Writer
April 15, 2013


2013 APR 15 (NewsRx) -- By a News Reporter-Staff News Editor at AIDS Weekly -- Fresh data on AIDS/HIV Research are presented in a new report. According to news reporting out of London, United Kingdom, by NewsRx editors, research stated, "The high diversity of HIV-1 has been shown to affect disease progression, transmission, and response to antiretroviral therapy and may influence HIV vaccine design. We describe the distribution trends of HIV-1 subtypes over a 7-year period among incident cases in a rural clinical cohort in Southwest Uganda and identify transmission clusters."

Our news journalists obtained a quote from the research from the London School of Hygiene and Tropical Medicine, "Viral RNA was extracted from cryopreserved plasma samples from 94 participants who seroconverted and enrolled between 2004 and 2010. Partial gag (p24) and env (gp41) genes were directly sequenced to identify subtypes and transmission clusters with more than 95% bootstrap values. Direct sequencing of the partial pol gene and use of individual participant sexual life histories were also used to confirm these transmission clusters. The overall gag/env subtype distribution was A 28% (n = 26), C 1% (n = 1), and D 45% (n = 42) and 27% (n = 25) were intergene unique recombinant forms. The proportions of subtype A, D, or recombinants showed no significant increasing or decreasing trend over this time period (p = 0.51). Phylogenetic analysis of the three genes confirmed 13 transmission clusters of which seven clusters were confirmed sexual partners using individual participants' sexual life histories. Subtype D has remained the predominant subtype in this population. From 2004 to 2010, there was no change in the proportions of these subtypes. Phylogenetic analysis and participants' sexual life histories revealed several transmission clusters. The high proportion of transmission clusters observed suggests continued high-risk sexual behavior and mixing in some individuals and possibly super transmitters in this presumed low-risk cohort, but also indicates that many transmissions occur in early HIV infection."

According to the news editors, the research concluded: "This calls for early and targeted effective prevention and treatment intervention in this population."

For more information on this research see: HIV-1 Subtype Distribution Trends and Evidence of Transmission Clusters Among Incident Cases in a Rural Clinical Cohort in Southwest Uganda, 2004-2010. Aids Research and Human Retroviruses, 2013;29(3):520-527. Aids Research and Human Retroviruses can be contacted at: Mary Ann Liebert Inc, 140 Huguenot Street, 3RD Fl, New Rochelle, NY 10801, USA. (Mary Ann Liebert, Inc. - www.liebertpub.com; Aids Research and Human Retroviruses - www.liebertpub.com/overview/aids-research-and-human-retroviruses/2/)

Our news journalists report that additional information may be obtained by contacting A. Kapaata, London Sch Hyg & Trop Med, London WC1, United Kingdom (see also AIDS/HIV Research).

Keywords for this news article include: London, Europe, Genetics, HIV/AIDS, Vaccines, Virology, RNA Viruses, Retroviridae, United Kingdom, HIV Infections, AIDS/HIV Research, Vertebrate Viruses, Primate Lentiviruses, Acquired Immunodeficiency Syndrome, Viral Sexually Transmitted Diseases

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