AIDS Weekly Plus
New Findings from A.M. Cavalcanti and Colleagues Has Provided New Data on Genetics and HIV/AIDS
April 29, 2013
2013 APR 29 (NewsRx) -- By a News Reporter-Staff News Editor at AIDS Weekly -- Investigators publish new report on Immune System Diseases and Conditions. According to news originating from Recife, Brazil, by NewsRx correspondents, research stated, "Determining the prevalence and type of antiretroviral (ARV) resistance among ARV-naive individuals is important to assess the potential responses of these individuals to first-line regimens. The prevalence of primary resistance and the occurrence of recent infections among individuals with human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS) were identified among recently diagnosed patients at five sexually transmitted disease/AIDS testing and counselling centres in the metropolitan region of Recife (RMR), Pernambuco, Brazil, between 2007-2009."
Our news journalists obtained a quote from the research, "One-hundred and eight samples were analysed using the Calypte® BED assay. Males predominated (56%), as did patients aged 31-50 years. Twenty-three percent presented evidence of a recent HIV infection. The median CD4+ T lymphocyte count was 408 cells/mm³ and the median viral load was 3.683 copies/mL. The prevalence of primary resistance was 4.6% (confidence interval 95%=1-8.2%) based on criteria that excluded common polymorphisms in accordance with the surveillance drug resistance mutation criteria. The prevalence of resistance to non-nucleoside reverse transcriptase, nucleoside/nucleotide reverse transcriptase and protease inhibitors were 3.8%, 1.5% and 0.8%, respectively. Fifty-seven percent of strains were from clade B, 37.7% were clade F and 3.1% were clade C; there were no statistically significant differences with respect to resistance between clades. Recent infection tended to be more common in men (p=0.06) and in municipalities in the south of the RMR (Jaboatao dos Guararapes and Cabo de Santo Agostinho) (p=0.046)."
According to the news editors, the research concluded: "The high prevalence of recent infection and the high prevalence of non-B strains in this poor Brazilian region merit further attention."
For more information on this research see: Primary resistance of HIV to antiretrovirals among individuals recently diagnosed at voluntary counselling and testing centres in the metropolitan region of Recife, Pernambuco. Memorias Do Instituto Oswaldo Cruz, 2012;107(4):450-7 (see also Immune System Diseases and Conditions).
The news correspondents report that additional information may be obtained from A.M. Cavalcanti, Setor de Virologia, Laboratorio Central de Saude Publica de Pernambuco, Recife, PE, Brazil.
Keywords for this news article include: Recife, Brazil, Genetics, HIV/AIDS, RNA Viruses, AIDS Therapy, Retroviridae, South America, HIV Infections, Vertebrate Viruses, Primate Lentiviruses, Human Immunodeficiency Virus, Viral Sexually Transmitted Diseases, Immune System Diseases and Conditions.
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