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Findings from French National Institute of Health and Medical Research (INSERM) Provides New Data about HIV/AIDS
Staff Writer
July 22, 2013


2013 JUL 22 (NewsRx) -- By a News Reporter-Staff News Editor at AIDS Weekly -- Data detailed on Immune System Diseases and Conditions have been presented. According to news reporting originating from Paris, France, by NewsRx correspondents, research stated, "The therapy and outcome of HIV infection have dramatically changed over the last 15 years, resulting in a change in renal complications. This study analyzed the characteristics of HIV-infected patients and biopsy-proven tubulointerstitial nephropathies to define disease patterns and therapeutic implications."

Our news editors obtained a quote from the research from the French National Institute of Health and Medical Research (INSERM), "& measurements A clinico-pathologic retrospective study of 59 consecutive renal biopsies showing predominant tubular and/or interstitial lesions in HIV-infected patients referred to the nephrology department between 1995 and 2011 was performed. HIV-associated nephropathy and vascular diseases were excluded from the study. Tubulointerstitial nephropathies accounted for 26.6% of 222 native renal biopsies performed in HIV-infected patients. Two pathologic groups were analyzed, tubulopathy and interstitial nephritis, which represented 49% and 51% of tubulointerstitial nephropathies, respectively. Most patients presented with AKI (76.3%) and high-grade proteinuria (57.7%). Drug-related nephrotoxicity was the leading cause (52.5%). Alternative etiologies included infections (15.2%), dysimmune disorders (8.5%), malignancies (3.4%), and chronic (10.2%) and acute (10.2%) tubulointerstitial nephropathies of undetermined origin. Tubulopathy was strongly associated with antiretroviral drug toxicity (75.9%) and mostly caused by tenofovir (55.2%), which was associated with proximal tubular dysfunction (87.5%), overt Fanconi's syndrome (37.5%), and nephrogenic diabetes insipidus (12.5%). Interstitial nephritis was associated with a broader spectrum of pathologic lesions and etiologies. In this series, tubulointerstitial nephropathies accounted for 26.6% of renal diseases in HIV-infected patients."

According to the news editors, the research concluded: "Considering the therapeutic implications of diagnoses of drug toxicity, infection, and dysimmune syndromes, this study underscores the importance of monitoring renal parameters in HIV-infected patients and points to the relevance of kidney biopsy to allow an accurate diagnosis."

For more information on this research see: Tubulointerstitial Nephropathies in HIV-Infected Patients over the Past 15 Years: A Clinico-Pathological Study. Clinical Journal of the American Society of Nephrology, 2013;8(6):930-938. Clinical Journal of the American Society of Nephrology can be contacted at: Amer Soc Nephrology, 1725 I St, Nw Ste 510, Washington, DC 20006, USA (see also Immune System Diseases and Conditions).

The news editors report that additional information may be obtained by contacting M. Zaidan, INSERM, UMR S 702, Paris, France.

Keywords for this news article include: Paris, France, Europe, Kidney, HIV/AIDS, Nephrology, RNA Viruses, Retroviridae, HIV Infections, Vertebrate Viruses, Primate Lentiviruses, Viral Sexually Transmitted Diseases, Immune System Diseases and Conditions

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