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AIDS Weekly Plus
Research Data from First Affiliated Hospital Update Understanding of HIV/AIDS and Cryptococcal Meningitis
Staff Writer
August 19, 2013


2013 AUG 19 (NewsRx) -- By a News Reporter-Staff News Editor at AIDS Weekly -- Current study results on Opportunistic Infections have been published. According to news reporting out of Guangdong, People's Republic of China, by NewsRx editors, research stated, "To investigate the clinical features, management, and prognosis of pulmonary cryptococcosis in non-acquired immunodeficiency syndrome (AIDS) patients. 24 cases of pulmonary cryptococcosis with accurate pathological diagnosis were retrospectively studied. 15 male patients and nine female patients were diagnosed at the first affiliated hospital of Sun Yat-sen University from November 1999 to November 2011. The mean age at the time of diagnosis was 44.2±11.3 years (range: 24 to 65 years)."

Our news journalists obtained a quote from the research from First Affiliated Hospital, "Among these patients, 13 had other comorbidities. 15 were symptomatic and the other nine were asymptomatic. The most common presenting symptoms were cough, chest tightness, expectoration, and fever. None had concurrent cryptococcal meningitis. The most frequent radiologic abnormalities on chest computed tomography (CT) scans were solitary or multiple pulmonary nodules, and masses or consolidations, and most lesions were located in the lower lobes. All patients had biopsies for the accurate diagnosis. Among the 24 patients, nine patients underwent surgical resections (eight had pneumonectomy via thoracotomy and one had a pneumonectomy via thoracoscopy). Five of the patients who underwent surgery also received antifungal drug therapy (fluconazole) for one to three months after the surgery. The other 15 only received antifungal drug therapy (fluconazole or voriconazole) for three to six months (five patients are still on therapy). The follow-up observation of 19 patients who had already finished their treatments lasted from two to 11 years, and there was no relapse, dissemination, or death in any of these patients."

According to the news editors, the research concluded: "Non-AIDS patients with pulmonary cryptococcosis have a good prognosis with appropriate management."

For more information on this research see: Pulmonary cryptococcosis in non-AIDS patients. The Brazilian Journal of Infectious Diseases, 2012;16(6):531-9 (see also Opportunistic Infections).

Our news journalists report that additional information may be obtained by contacting J.Q. Yu, Dept. of Pulmonary Medicine, The First Affiliated Hospital of Sun Yat-sen University, 58 ZhongShan Rd, Guangzhou, Guangdong, People's Taiwan.

Keywords for this news article include: Asia, Antifungals, Drugs, Surgery, Therapy, Guangdong, Cryptococcosis, Cryptococcal Meningitis, Opportunistic Infections, People's Republic of China.

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