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AIDS Weekly Plus
Findings in the Area of HIV/AIDS Reported from French National Institute of Health and Medical Research (INSERM)
Staff Writer
August 19, 2013


2013 AUG 19 (NewsRx) -- By a News Reporter-Staff News Editor at AIDS Weekly -- Current study results on Immune System Diseases and Conditions have been published. According to news originating from Bordeaux, France, by NewsRx correspondents, research stated, "Mechanistic models, based on ordinary differential equation systems, can exhibit very good predictive abilities that will be useful to build treatment monitoring strategies. In this review, we present the potential and the limitations of such models for guiding treatment (monitoring and optimizing) in HIV-infected patients."

Our news journalists obtained a quote from the research from the French National Institute of Health and Medical Research (INSERM), "In the context of antiretroviral therapy, several biological processes should be considered in addition to the interaction between viruses and the host immune system: the mechanisms of action of the drugs, their pharmacokinetics and pharmacodynamics, as well as the viral and host characteristics. Another important aspect to take into account is clinical progression, although its implementation in such modelling approaches is not easy. Finally, the control theory and the use of intrinsic properties of mechanistic models make them very relevant for dynamic treatment adaptation."

According to the news editors, the research concluded: "Their implementation would nevertheless require their evaluation through clinical trials."

For more information on this research see: Dynamical models of biomarkers and clinical progression for personalized medicine: The HIV context. Advanced Drug Delivery Reviews, 2013;65(7):954-965. Advanced Drug Delivery Reviews can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; Advanced Drug Delivery Reviews - www.elsevier.com/wps/product/cws_home/505508)

The news correspondents report that additional information may be obtained from M. Prague, INSERM, ISPED, Center INSERM U897, F-33000 Bordeaux, France (see also Immune System Diseases and Conditions).

Keywords for this news article include: France, Europe, Bordeaux, HIV/AIDS, Treatment, RNA Viruses, Retroviridae, HIV Infections, Vertebrate Viruses, Primate Lentiviruses, Clinical Trials and Studies, Viral Sexually Transmitted Diseases, Immune System Diseases and Conditions

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